US Patents on Copper-Peptide Induced
Tissue Regeneration by Dr. Loren Pickart

Dr. Pickart's US patents on tissue regeneration are assigned to Skin Biology, Inc. and ProCyte Corporation. Dr. Pickart's most recent research and improved second generation technology has been discovered and patented at Skin Biology. An additional 135+ patents on these topics have been issued in various foreign countries.

Second Generation Patents, Skin Biology, Inc.

Skin Regeneration and Safer Suntanning

US 5,698,184   Compositions and methods for skin tanning and protection
US 5,382,431   Tissue protective and regenerative compositions
US 5,858,993   Starch-metal complexes for skin and hair
US 5,888,522   Tissue protective and regenerative compositions .

Hair Regrowth and Hair Loss Prevention

Folligen®
US 5,554,375   Tissue protective and regenerative compositions

First Generation Patents, ProCyte Corporation

Wound Healing (Chronic Skin Ulcers, Surgical Wounds, Burns)

Iamin^® (Prezatide Copper Acetate)
US 5,164,367   Compositions for accelerating wound healing in mammals containing cupric salt or complexes with amino acid or peptide.
US 4,937,230   Method for healing wounds in horses using a copper complex of Glycyl-L-Histidyl-L-lysine or derivatives on the affected area.
US 4,877,770   New glycyl-histidyl-lysine ester copper complex compounds with anti-inflammatory and superoxide dismutase activity useful for enhancing wound healing.
US 4,810,693   Copper-glycyl-L-histidyl-L-lysine complexes enhance the healing of wounds and sores.
US 4,760,051   Compositions containing glycyl-1-histidyl-1-lysine copper(II) enhance the wound healing process without evoking an antigenic response.
US 4,665,054   New glycyl-L-histidyl-L-lysine-copper derivatives of improved resistance to proteolytic enzymes and better fat solubility for use in inhibiting thromboxane production and enhancing wound healing.

See also:
Pickart, L., "Iamin (Prezatide Copper Acetate): A Human Growth Factor with Multiple Wound-Healing Properties", Biology of Copper Complexes, Clifton, NJ, 1987, pp. 273-285.

Hair Growth and Hair Loss Prevention

Tricomin^® and GraftCyte^®
US 5,550,183   Metal-peptide compositions and methods for stimulating hair growth.
US 5,214,032   New glycyl-histidyl-lysyl copper compounds used in stimulating hair growth.
US 5,177,061   Compositions for stimulating hair growth containing cupric complexes of peptide derivatives including. glycyl-l- histidyl-l-lysine n-octyl ester.
US 5,120,831   New metal peptide complexes and derivatives used for stimulating growth of hair in warm-blooded animals, especially humans.

Other Tissue Regeneration Patents

Iamin^® - IB Treat for Inflammatory Bowel Disease (Crohn’s Disease and Ulcerative Colitis)
US 5,023,237   Use of polypeptide or its copper complex for cytoprotection in treatment of intestinal and stomach ulcers, and to facilitate wound healing.

Cytril - Prevention of Ulcers That Occur Due to Arthritis Medication/Aspirin
US 5,145,838   Methods and compositions for healing ulcers and peptide derivatives.
US 4,767,753   Copper complexes of histidyl-lysine polypeptide(s) for reducing stomach secretions, increasing stomach mucous and preventing ulcers.

Osteamin - Bone Repair
US 5,059,588   New and known copper peptide complexes for bone healing containing glycyl-histidyl-lysine and lysyl-histidyl-glycine.

Treatment of Aging Skin
US 5,348,943   Cosmetic and skin treatment compositions.
US 5,135,913   Skin treatment composition comprises GHL-CU or derivatives for improving skin health, increasing subcutaneous fat, dermal thickness and density.

Blockage of Reperfusion Injury - Tissue Injury After Stoppage of Blood Flow
US 5,118,665   New anti-oxidative and anti-inflammatory metal peptide complexes - containing. glycyl histidyl and lysine residues used to enhance or restore resistance to oxidative or inflammatory damage.
Iamin^® and Tricomin^® are registered trademarks of ProCyte Corporation